Thursday, December 13, 2012

Could hydrolysis of arsenic substituted DNA be prevented? Protection arises from stacking interactions.

Chem Commun (Camb). 2012 Apr 14;48(30):3626-8. 
Wang J, Gu J, Leszczynski J. 
Interdisciplinary Nanotoxicity Center, Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39217, USA. 
Abstract - Investigation of the hydrolysis of dinucleoside-arsenate-deoxyguanylyl-3',5'-deoxyguanosine (dGAsdG(-)) reveals that base-stacking in DNA increases the resistance of As-DNA towards hydrolysis. Base-stacking raises the activation energy of hydrolysis. Hydrolysis of As-DNA is found to be endothermic. The hydrolysis stability of As-DNA should be higher than that estimated based on arsenate diester models.

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